Synthesis and biological evaluation of bicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes

Tang Peng Cho; Lin Zhi Gang; Yang Fang Long; Wang Yang; Wang Qian; Zhang Lei; Luo Jing Jing; Feng Ying; Yan Pang Ke; Leng Ying; Feng Jun

doi:10.1016/j.bmcl.2010.04.138

Synthesis and biological evaluation of bicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3521-5. doi: 10.1016/j.bmcl.2010.04.138. Epub 2010 May 18.

Authors

Tang Peng Cho¹, Lin Zhi Gang, Yang Fang Long, Wang Yang, Wang Qian, Zhang Lei, Luo Jing Jing, Feng Ying, Yan Pang Ke, Leng Ying, Feng Jun

Affiliation

¹ Shanghai Hengrui Pharmaceuticals Co., Ltd, Shanghai, China. tangpc@shhrp.com

PMID: 20488704
DOI: 10.1016/j.bmcl.2010.04.138

Abstract

A series of novel bicyclo[3.3.0]octane derivatives have been synthesized and found to be dipeptidyl peptidase 4 (DPP-4) inhibitors. Compounds 10a and 10b demonstrate good efficacies in oral glucose tolerance tests.

MeSH terms

Animals
Bridged Bicyclo Compounds / chemical synthesis*
Bridged Bicyclo Compounds / pharmacology
Diabetes Mellitus, Type 2 / drug therapy*
Dipeptidyl-Peptidase IV Inhibitors / chemical synthesis*
Dipeptidyl-Peptidase IV Inhibitors / pharmacology
Dose-Response Relationship, Drug
Glucose Tolerance Test
Mice
Mice, Inbred Strains
Octanes / chemical synthesis*
Octanes / pharmacology

Substances

Bridged Bicyclo Compounds
Dipeptidyl-Peptidase IV Inhibitors
Octanes